For ages man has been wondering: “What disease does Misaka Shiori actually have?” I will explore the possibilities to finally answer this age old question.

Now I may not be a doctor but I’ve seen enough House MD to know how this “diagnose” thing works; all I have to do is be an arrogant asshole…maybe check out her symptoms. Sooooo let’s get started.

• She’s weak and has chronic fevers.
• She carries a bag full of cold medicine because a simple cold could kill her. (Weakened Immune System)
• She’s very thin. (weight loss)
• She’s dying.

Also let’s not forget that Shiori is a depressed wreck that tried to slit her wrists with a boxcutter and sleeps with the first guy she meets for comfort. Speaking of which, let’s take a look at one of her H-scene…now i don’t really remember it very well but I think it went a little bit like this…

Shiori: OH YUICHI TAKE ME NAO!
Yuichi: Hold your horses girl, let me put on a condom first.
Shiori: Oh Yuichi, sex with a condom is so dull. I like to feel men’s hot load inside me.
Yuichi: Wait a minute, men? Aren’t I your first?
Shiori: Of course not silly…
Yuichi: Just how many different guys did you have unprotected sex with?
Shiori: I kinda lost track at 83…
Yuichi: …
Shiori: Why are you staring at me like that?
Yuichi: You said you had a cold!
Shiori: Does it matter? Stick it in me already!
Yuichi: I’m not touching you with a 10 foot pole you crazy bitch, I’m getting my ass out of here.
Shiori: NOOOOOOOO YUICHI I’LL KILL MYSELF IF YOU GO AWAY!
Yuichi: Yeah whatever, I’m getting myself a piece of foxy Makoto Ass.

Now let’s put all these facts together: Weakened immune system, dying and a slut. I think it’s pretty obvious now, it’s AIDS. But let’s look at things on the bright side, once she’s dead she won’t be able to spread AIDS anymore and her sister Kaori will be able to live a happy, Nag-free life. And now if you’ll excuse me I’m going look at Makoto’s CG for several hours.